Search and Destroy: The Doom of Glioblastoma Multiform
In 2010, Glioblastoma Multiform (GBM) claimed 2,000 Americans and put more than 3,000 on its list. GBM is extremely aggressive and is a Stage IV malignant tumor. Patients diagnosed with GBM hardly make it past the first anniversary of diagnosis. A better understanding of GBM is urgent as many of these brain tumors are not discovered until they are in Stage IV and is taking over the brain (see above image).
GBM is mostly found as a primary tumor and is noted for its extreme motility and local invasiveness through the white matter of the brain. Healthy, adult neurons are normally terminally differentiated and have lost their ability to actively seek destinations as they do in early development. Not GBM cells who appear to have re-gained their functions of the past. Their motility renders a complete and successful resection of cancerous brain-matter extremely difficult that will end in novel tumor growth.